When the arteritis swells as a result of injury, polyarteritis nodosa (PAN) ensues. The effect primarily affects the small to medium arteries, but it can also become problematic when it affects the blood vessels owing to immune system dysfunction. Before the signs become chronic, you should see a doctor if you have any of these complications. The most frequently affected organs are the kidneys, skin, joints, muscles, nerves in the peripheral regions, and the digestive tract, though any organ (apart from the lungs) may be impacted.
An uncommon multi-system condition called polyarteritis nodosa causes extensive inflammation, weakness, and damage to the small and medium-sized arteries. Any organ or organ system, including those that supply the kidneys, heart, gut, neurological system, and/or skeletal muscles, may be impacted. destruction to the afflicted arteries may cause tissue destruction and loss (necrosis) in some affected locations, abnormally elevated blood pressure (hypertension), “ballooning” (aneurysm) of an artery wall, the production of blood clots (thrombosis), restriction of blood supply to some tissues, and/or blood clots.
The illness is more prevalent in men and is more likely to manifest in the early stages of middle age, between the ages of 40 and 50. Although the precise origin of polyarteritis nodosa is unknown, it is obvious that any number of medications, immunizations, or infections (bacterial or viral), including strep or staph infections, or the hepatitis B virus, can produce an attack. Many scientists believe that immune system disruptions are to blame for the illness. It was necessary to do a biopsy to confirm the diagnosis, which revealed small to medium-sized arteries with alternating zones of stenosis (constriction or blockage) and dilatation.
It is unknown what specifically causes polyarteritis nodosa. The majority of patients have no known predisposing factors. Unknown viral or bacterial infections could be the reason. Drug users, particularly those who abuse amphetamines, and people with hepatitis B (a liver infection) have both been shown to have polyarteritis nodosa. (Use “Hepatitis B” as your search phrase in the Rare Disease Database to learn more about this illness.) An allergic response to certain medications and immunizations has also been connected to this condition. Most medical professionals think that polyarteritis nodosa is an autoimmune condition.
Autoimmune diseases are brought on when the body’s natural defenses (such as antibodies) opposing “foreign” or invasive organisms start targeting healthy tissue for unknown reasons. The blood channels known as arteries transport oxygen-rich blood to organs and tissues. There is no recognized etiology for polyarteritis nodosa. The condition is brought on by certain immune cells that target the diseased arteries. The damaged arteries do not provide the necessary oxygen and nutrition to the tissues they feed. The result is damage.
Signs and Symptoms:
Small and medium-sized arteries are primarily affected by polyarteritis nodosa. Any organ or system of organs, including the arteries feeding the kidneys, heart, gut, neurological system, and/or skeletal muscles, may be damaged. destruction to the afflicted arteries may cause tissue destruction and loss (necrosis) in some affected locations, abnormally elevated blood pressure (hypertension), “ballooning” (aneurysm) of an artery wall, the production of blood clots (thrombosis), restriction of blood supply to some tissues, and/or blood clots. There may be pain in the joints, muscles, abdomen, and testicles. The kidneys’ tiny and medium-sized arteries are most frequently affected. Lungs are far less frequently impacted.
- Continent pain
- A diminished appetite
- Fatigue Fever
- Joint pain
- Muscle pain
- Unintentional loss of weight
Once polyarteritis nodosa is thought to be the cause, an arteriogram or biopsy is typically ordered to confirm the diagnosis. A dye is injected into the bloodstream during an arteriogram to enable visualization of the blood vessels, which can reveal aneurysms or blood vessel narrowing indicative of vasculitis. A biopsy of the affected area may be done, depending on the site of involvement, to attempt and confirm the presence of vasculitis inside the tissue. Arteriograms and biopsies are only advised for organ sites if inspection, laboratory testing, or other imaging studies have revealed abnormal findings.
- Using medical history, check for polyarteritis nodosa symptoms.
- Physical examination to identify organ involvement sites and rule out other conditions that might present similarly.
- To look for characteristics that could point to inflammation or organ Involvement, doctors may perform blood tests and urine.
- X-rays, computed tomography (CT), and magnetic resonance (MR) scans are imaging procedures that can reveal abnormalities in the affected areas.
Polyarteritis nodosa can be effectively treated with homeopathy since it treats the underlying dysfunctional immune system. Being an auto-immune disease, polyarteritis nodosa can be successfully treated with a carefully selected, deeply acting, constitutional homeopathic drug. Integrating a holistic strategy will strengthen the immune system, regulate the underlying illness process, and thereby lessen polyarteritis nodosa symptoms. Following are a few medicines that can be used for polyarteritis nodosa.
- Natrum Mur
The most frequently prescribed course of medicine for Polyarteritis Nodosa includes immune suppressants, corticosteroids, and antiviral agents. By lowering inflammation as they replenish specific hormones in the body, these drugs aid in the reduction of Polyarteritis Nodosa symptoms. The immune system is kept at bay by a corticosteroid, which helps to protect your arteries from damage. However, they must be used in conjunction with immunosuppressive drugs. Comparable drugs like methotrexate, azathioprine, or mycophenolate are used since they allow the dosage of the steroid to be decreased as well. Cyclophosphamide is used if the problem is especially severe.
Most polyarteritis nodosa instances cannot be avoided. Hepatitis-related polyarteritis nodosa may be prevented by receiving a hepatitis B vaccination and staying away from risky behaviors including unprotected sex and sharing needles when using intravenous drugs. If you don’t need a special diet, cut back on starchy items like bread, potatoes, grains, and pasta in favour of vegetables and fruits that are fresh. Also to be avoided are chemically processed foods and meat grown on wheat.