An acquired (not hereditary) condition called paroxysmal nocturnal hemoglobinuria (PNH) causes the synthesis of blood cells to be hindered and to die off too soon. White blood cells (leukocytes), which guard the body against infections; platelets (thrombocytes), which are involved in blood clotting; and red blood cells (erythrocytes), which deliver oxygen, are all impacted by the condition. Paroxysmal signs and symptoms, which are abrupt, recurrent episodes of signs in patients with PNH, can be brought on by bodily pressures, including infections or physical exercise. Hemolysis, or premature red blood cell breakdown, occurs during these events.



Red blood cells prematurely fragment in a rare condition known as paroxysmal nocturnal hemoglobinuria (PNH). It is an acquired disease of hematopoietic stem cells. The spongy inside of the body’s long bones, the bone marrow, is where hematopoietic stem cells are produced. These cells multiply and eventually transform into platelets, white blood cells, and red blood cells. People with Paroxysmal Nocturnal Hemoglobinuria have some faulty hematopoietic stem cells, which result in the production of dysfunctional blood cells. These PNH-related red blood cells are highly vulnerable to early death by the complement system, a specific component of the body’s immune system. Hemolysis, or the breakdown of red blood cells by complement, results in episodes of hemoglobinuria, or the presence of hemoglobin in the urine. The red, iron-rich, oxygen-containing component of the blood is called hemoglobin.

Hemoglobinuria patients may have urine that is black or blood-colored. The pee has concentrated overnight while you slept, and this finding is most noticeable in the morning. However, hemolysis is a continuous process (i.e., it does not only happen at night) in people with PNH. There might not always be evidence of hemoglobin in the urine. Individuals with PNH are more susceptible to continually developing potentially lethal blood clots (thromboses), in addition to hemolysis. In addition, affected individuals have a certain amount of bone marrow dysfunction.



Paroxysmal Nocturnal Hemoglobinuria is a hereditary condition that alters the function of your platelets and red blood cells. The defect sets off a series of circumstances that result in serious and possibly fatal medical problems. The process begins in the bone marrow, where stem cells are transformed into mature red blood cells, white blood cells, and platelets by your body. One stem cell in PNH mutates or transforms into an aberrant stem cell due to a gene called PIGA. This cell multiplies and creates more aberrant stem cells, which develop into defective platelets and red blood cells.

A PIGA gene mutation that affects a number of hematopoietic stem cells, producing defective “PNH” blood cells, and a mechanism that causes the proliferation and growth of these faulty stem cells are both required for the formation of PNH. As is the case in the majority of cases of inherited aplastic anemia, PNH most likely develops in the context of immunological bone marrow failure. Researchers think that although healthy stem cells are eliminated, dysfunctional PNH stem cells escape the immune system’s mistaken attack and proliferate, causing PNH to form.

Signs and Symptoms:


PNH symptoms arise from both insufficient blood cell synthesis by the bone marrow and the creation of faulty blood cells. Each individual experiences the condition differently, including its specific symptoms and rate of advancement. Some people may experience minor symptoms that are stable for years, while others may experience more severe symptoms that can lead to life-threatening consequences. It is important to keep in mind that not everybody who is affected will likely experience every one of the signs and symptoms listed below. People who are affected should talk to their specialists and healthcare providers about their particular case, any associated symptoms, and the overall outlook.

The main clinical finding connected to Paroxysmal Nocturnal Hemoglobinuria is hemolysis, which is the premature destruction of red blood cells. Haemoglobin can appear in the urine even if hemolysis affects many people who do not have measurable hemoglobin in their pee. The outer membrane of a red blood cell disintegrates during hemolysis, releasing hemoglobin.

  • Dyspnea, or shortness of breath.
  • Kidney issues.
  • Swallowing issues (dysphagia).
  • Stomach cramps.
  • Stomach ache.
  • Erection problems.



To check for PNH symptoms, medical professionals may perform a number of tests. Depending on the outcomes of that test, they might study your blood cells using a procedure called flow cytometry. Tests that healthcare professionals may do include:

  • Reticulocyte count: Your bone marrow’s reticulocytes, or immature red blood cells, are counted to see how many there are. Medical experts use reticulocyte counts to estimate the amount of healthy red blood cells that your bone marrow is producing.
  • Test for hemoglobin: hemoglobin is a protein that clears away the debris left behind by harmed red blood cells. Low amounts of haptoglobin could indicate red blood cell injury.
  • This test examines the liver’s ability to process bilirubin, which may arise when red blood cells degrade.
  • Healthcare professionals check for indicators of blood abnormalities such as anemia and thrombocytopenia and anemia during a complete blood count with differential (CBC w/diff).
  • Basic metabolic panel (BMP): Medical professionals seek indications of renal failure and chronic kidney disease.
  • Urinalysis: This test may reveal hemosiderosis (excess iron deposits) and hemoglobinuria (blood in the poop) symptoms.

Homeopathic Treatment:


Homeopathy can be used in addition to conventional pancytopenia and hypoplastic marrow therapy for PNH. It is particularly good at strengthening the structure, which lowers the likelihood of repetition. The medicines used in the homeopathic medical system are prepared in such a way that they boost the body’s immunity. In essence, this shows that homeopathic therapy enhances the body’s capacity to combat sickness. Homeopathy is a safe, natural medical method that enhances the body’s natural healing process by administering modest doses of well-researched drugs. Following is a list of some homeopathic remedies that can be used to treat Paroxysmal Nocturnal Hemoglobinuria:

  • Natrum Mur
  • Ferrum Met
  • Cinchona
  • Nit-acid
  • Phosphorous
  • Arsenic Album
  • Ferrum Phos
  • Kali Arsenicosum
  • Hamamelis
  • Calc Phos
  • Amon Carb,
  • Alumina

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